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A consistent and robust source of pooled donor human hepatocytes is important for DMPK studies With our new proprietary algorithm we are able to predict yield viability and functional phenotype of DonorPlex Human Hepatocytes which in turn will support more consistent results in your DMPK Each batch of pooled 10-donor mixed gender human hepatocytes is characterized for viable yield and CYP1A2 CYP2A6 CYP2B6 CYP2C9 CYP2C19 CYP2E1 CYP3A4 UGT SULT OAT1B1/3 OCT and NTCP activities With our large inventory of single donor human hepatocyte lots and using our proprietary algorithm to predict phenotype we can also custom produce a pooled donor hepatocyte batch with the phenotype to fit your needs The DonorPlex Hepatocytes - suspension qualified hepatocytes are ideally suited for short-term ( 4hrs) in vitro drug clearance assays The suspension qualified hepatocytes are not suitable for applications that require hepatocytes cultured in adhered monolayer
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A consistent and robust source of pooled donor human hepatocytes is important for DMPK studies With our new proprietary algorithm we are able to predict yield viability and functional phenotype representing the average human populations The DonorPlex Pooled Donor Human Hepatocytes 10 Donor Female is a single gender 10-donor pool designed to function like the average female liver Each batch is characterized for viable yield and CYP1A2 CYP2A6 CYP2B6 CYP2C9 CYP2C19 CYP2E1 CYP3A4 UGT SULT OAT1B1/3 OCT and NTCP activities With our large inventory of single donor human hepatocyte lots and using our proprietary algorithm to predict phenotype we can also custom produce a pooled donor hepatocyte batch with the phenotype to fit your needs DonorPlex Pooled Donor Human Hepatocytes 10-Donor Female Hepatocytes are ideally suited for short-term ( 4hrs) in vitro drug clearance assays in a single gender pool
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Innovative Grade US Origin Hamster Syrian Gold Serum 10ml - Innovative Grade US Origin Hamster Syrian Gold Serum from Innovative Research is manufactured using whole blood collections from type Syrian Gold hamsters. The animals used for this material are of US Origin, ensuring that only the highest-quality material is used for the production of the serum.
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Innovative Grade US Origin Bovine Serum 500ml - Innovative Grade US Origin Bovine Serum from Innovative Research is manufactured using whole blood collections from cows in USDA-approved facilities. The animals used for this material are of US Origin, ensuring that only the highest-quality material is used for the production of the serum.
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TGF- 1 (transforming growth factor beta 1) is one of three closely related mammalian members of the large TGF- 1 superfamily that share a characteristic cystine knot structure TGF- 1 -2 and -3 are highly pleiotropic cytokines that act as cellular switches to regulate processes such as immune function proliferation and epithelial-mesenchymal transition Each TGF- isoform has some non-redundant function for TGF- 1 mice with targeted deletion show defects in hematopoiesis and endothelial differentiation and died of overwhelming inflammation TGF- 1 signaling begins with high-affinity binding to a type II ser/thr kinase receptor termed TGF- RII This receptor then phosphorylates and activates a second ser/thr kinase receptor TGF- RI (also called activin receptor like kinase (ALK)-5) or alternatively ALK-1 This complex phosphorylates and activates Smad proteins that regulate transcription
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Innovative Grade US Origin Bovine Serum 100ml - Innovative Grade US Origin Bovine Serum from Innovative Research is manufactured using whole blood collections from cows in USDA-approved facilities. The animals used for this material are of US Origin, ensuring that only the highest-quality material is used for the production of the serum.
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IgM is a highly conserved antibody in vertebrates and is expressed early during immune response. It exists as a pentamer and is secreted by peritoneal B cells.
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Innovative Grade US Origin Guinea Pig Complement Serum 10ml - Innovative Grade US Origin Guinea Pig Complement Serum from Innovative Research is manufactured using whole blood collections from guinea pigs. The animals used for this material are of US Origin, ensuring that only the highest-quality material is used for the production of the serum. This product is processed using a proprietary process that preserves complement activity. We do not recommend thawing this product for aliquoting, as this can impact the complement activity
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Beta-galactosidase Enzyme Donor Stabilization Buffer (50 mL) consists of a buffer specifically optimized to stabilize the beta-galactosidase fragment known as enzyme donor (Alpha fragment) The buffer can extend the shelf life of the enzyme donor to up to 12 months at 2-8C Without this buffer the enzyme donor is highly instable and loses activity at a high rate For in vitro research use only
Encompass Procurement Services Non-distribution item offered as a customer accommodation; additional freight charges may apply. Learn More